NVP-TAE 226 - CAS# 761437-28-9 hlorobenzyl)-N2 N2-dimethyl-N1-(pyridin-2-yl)ethane-1 2-diamine hydrochloride Smiles: CCN1C=C(CCC)C2N=C(NC(=O)C1=2)C1=CC(=CC=C1OCCC)S(=O)(=O)N1CCN(CCO)CC1

Smiles: CCN1C=C(CCC)C2N=C(NC(=O)C1=2)C1=CC(=CC=C1OCCC)S(=O)(=O)N1CCN(CCO)CC1

CAS Number: 1092578-46-5

Epub 2008 Oct 18

InChi: InChI=1S/C27H44O3/c1-18(8-6-14-26(3

Molecular Weight: 784

NVP-TAE 226 - CAS# 761437-28-9 hlorobenzyl)-N2 N2-dimethyl-N1-(pyridin-2-yl)ethane-1 2-diamine hydrochloride Smiles: CCN1C=C(CCC)C2N=C(NC(=O)C1=2)C1=CC(=CC=C1OCCC)S(=O)(=O)N1CCN(CCO)CC1TAE226 is a novel and potent ATP competitive inhibitor of FAK and IGF IR with potential anticancer activity. TAE226 can block FAK and IGF IR signaling pathways. TAE226 inhibited the phosphorylation of FAK as well as the downstream effectors AKT, extracellular signal related kinase, and S6 ribosomal protein in multiple glioma cell lines. TAE226 induced a concentration dependent decrease in cellular proliferation with an associated G(2) cell cycle