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Smiles: FC1C=C(C=C(F)C=1CN1CCOCC1)C1=CC=CC2=NC=C(N=C21)C1C=NN(C=1)C1CCNCC1
InChiKey: PQXINDBPUDNMPE-UHFFFAOYSA-N
Molecular Weight: 244
InChi: InChI=1S/C30H31FN2O
22)15-11-4-2-1-3-9(11)13(17)18/h1-7
Ro 48-8071 viol Smiles: FC1C=C(C=C(F)C=1CN1CCOCC1)C1=CC=CC2=NC=C(N=C21)C1C=NN(C=1)C1CCNCC1Ro 48 8071 is an orally active cholesterol synthesis inhibitor or a 2,3 oxidosqualene: lanosterol cyclase (OSC) inhibitor. OSC (EC 5. 4. 99. 7) represents a unique target for a cholesterol lowering drug. Partial inhibition of OSC should reduce synthesis of lanosterol and subsequent sterols, and also stimulate the production of epoxysterols that repress HMG CoA reductase expression, generating a synergistic, self limited negative regulatory loop.