JSH-23 - CAS# 749886-87-1 Catalog No.:M9452-10 FGFR inhibitor ARQ 087 binds

FGFR inhibitor ARQ 087 binds to and potently inhibits the activity of FGFR subtypes 1

1446506-78-0

Natural Yellow 2

p) treatment induces 37% regression of tumor volume within 1 week

8-tetramethyl-2-[(4R

JSH-23 - CAS# 749886-87-1 Catalog No.:M9452-10 FGFR inhibitor ARQ 087 bindsJSH 23 is a nuclear factor kappa B (NF B) nuclear translocation inhibitor. JSH 23 inhibits LPS and cytokine induced nuclear translocation of the p65 subunit of NF kB as analyzed by EMSA and western blot. JSH 23 treatment significantly reversed the nerve conduction and nerve blood flow deficits seen in diabetic animals. Reduction in mechanical pain threshold was also partially corrected by the treatment. Protein expression studies showed that nuclear