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ALK4 and ALK7) with potential anticancer activity
Smiles: O=C(NCC1C=CN=CC=1)[C@]12C[C@@]3(C[C@H](C1)C[C@@H](C3)C2)C1C=CC(Cl)=CC=1
30675-13-9
PHF8 at IC50 ~0
InChi: InChI=1S/C16H21N3O4S2/c1-7-11-10(8(2)20)14(21)19(11)12(15(22)23)13(7)25-9-5-18(6-9)16-17-3-4-24-16/h7-11
Vinflunine tartrate Ivabradine Hydrochloride ALK4 and ALK7) with potentialVinflunine is a bi fluorinated derivative of the semi synthetic vinca alkaloid vinorelbine with antitubulin, antineoplastic, and antiangiogenic activities. Vinflunine inhibits tubulin assembly without any stablization of assembled microtubules at concentrations comparable to those of other vinca alkaloids such as vincristine, vinblastine and vinorelbine; this effect on microtubule dynamics results in cell cycle arrest in mitosis and apoptosis.
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