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1-Naphthohydroxamic acid Catalog No.:M33126-C Smiles: CS(=O)(=O)OCCOCCOCCOCCOCCOCC#C

SKU: 36418893715

4.2
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Description

Smiles: CS(=O)(=O)OCCOCCOCCOCCOCCOCC#C

orally active and brain-penetrant inhibitor of Bruton tyrosine kinase (BTK)

Sorivudine (BV-araU) inhibits strains of HSV-1 and HSV-2 (wild-type strains VR-3 and UW-268) with ID50s (50% inhibitory dose) of 0

Solubility: DMSO : 100 mg/mL (648

Smiles: C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC1=CNC=N1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(N)=O

1-Naphthohydroxamic acid Catalog No.:M33126-C Smiles: CS(=O)(=O)OCCOCCOCCOCCOCCOCC#C1 Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 M. 1 Naphthohydroxamic acid is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 M). 1 Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity. 1 Naphthohydroxamic acid can induce tubulin acetylation. Product information CAS Number: 6953 61 3 Molecular

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