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8%) are also observed
InChiKey: FGXWKSZFVQUSTL-UHFFFAOYSA-N
RKI 1447 (20-80 μM
CAS Number: 919091-63-7
Chemical Name: tetrasodium bis((2S)-2-{[4-(2-{2-amino-4-oxo-3H
MK-2461 1762 8%) are also observedMK 2461 is a novel ATP competitive multitargeted inhibitor of activated c Met with a mean IC50 of 2. 5 nM. IC50 value: 2. 5 nM Target: c Metin vitro: MK 2461 inhibits the kinase activity of human c Met with a mean IC50 of 2. 5 nM in the presence of 50 M ATP. Ron (IC50 = 7 nM) and Flt1 (IC50 = 10 nM) are inhibited by MK 2461 with similar potencies to c Met (IC50 = 2. 5 nM), whereas nine other kinases, including FGFR1, FGFR2, FGFR3, PDGFR, KDR, Flt3,
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