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The percentage of UR (apoptosis portion) area increases gradually according to the concentration of DuP-697 from 7% in control group to 52% in 100 nM DuP-697
2-3H3/t20-
5S)-3-amino-5-(trifluoromethyl)piperidin-1-yl)quinoline-8-carbonitrile hydrochloride
Smiles: CCN(CC)C(=O)C1C=CC=C(CO)C=1
and the stimulation can be blocked by a PI3-K inhibitor wortmannin
CYM-2503 Size:Contact [email protected] for quotation The percentage of UR (apoptosisCYM2503 is a positive allosteric modulator (PAM) of the GAL2 receptor which potentiates galanin induced IP1 production in vitro. CYM2503 potentiated the galanin stimulated IP1 accumulation in HEK293 cells stably expressing GalR2 receptor, whereas it exhibited no detectable affinity for the (125)I galanin binding site of GalR2 receptor, an effect consistent with that of a positive allosteric modulator. Product information CAS Number: 1308833 36 4
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