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Homosalate (HMS
9)6-4-2-1-3-5-6/h3-10
Chemical Name: (R)-2-(6-(5-chloro-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1-oxoisoindolin-2-yl)-N-((S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl)propanamide
InChi: InChI=1S/C24H25N5O3S/c1-15(2)33(30
31)15-17-7-5-4-6-8-17/h4-8
mTOR-IN-1 - CAS# 1207358-59-5 Catalog No.:M9817-2 Homosalate (HMSmTOR IN 1 is a remarkably selective mTOR inhibitor with a Ki of 1. 5 nM. mTOR IN 1 suppresses mTORC1 and mTORC2 in cellular and in vivo pharmacokinetic (PK) pharmacodynamic (PD) experiments. In Vitro: mTOR IN 1 (Compound 12i) inhibits mTOR with a Ki of 1. 5 nM, 500 fold selectivity over closely related PI3 kinases. mTOR IN 1 inhibits NCI PC3 and MCF7neo Her2 cells proliferation with IC50s of 150 nM and 57 nM, respectively[2]. In Vivo: mTOR IN 1