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KPT-330 potentiates the antitumor activity of gemcitabine in human pancreatic cancer through inhibition of tumor growth
EZH2 inhibitor efficacy in non-Hodgkin's lymphoma does not require suppression of H3K27 monomethylation
CAS Number: 754240-09-0
Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment
Erratum in: Nat Chem Biol
XAV939 - Wnt Antagonist. CAS# 284028-89-3 size:10mg solid KPT-330 potentiates the antitumor activityXAV939, CAS No. 284028 89 3, is a potent and selective Wnt pathway antagonist. It functions to stabilize Axin by inhibiting the poly ADP ribosylating enzymes tankyrase 1 and tankyrase 2 with IC50 of 11 nM and 4 nM, respectively. It has been used to study Wnt dependent cancers. In addition, XAV939 was shown to stabilize Axin2 level in oligodendrocyte precursor cells in the spinal cord and accelerated their differentiation and myelination after hypoxic