ABT-100 - CAS# 450839-40-4 size:2mg solid MP-470 (10 μM) inhibits c-Met

MP-470 (10 μM) inhibits c-Met phosphorylation and sensitizes cells to radiation

A single dose of ABT-199 in three patients with refractory chronic lymphocytic leukemia resulted in tumor lysis within 24 h

Smiles: C[C@H](NC(=O)[C@@H](O)C1=CC(F)=CC(F)=C1)C(=O)N[C@@H]1C(=O)N(C)C2=CC=CC=C2C2=CC=CC=C21

1258861-21-0 (Taladegib hydrochloride)

and inhibits NMDA-induced increase in cytosolic Ca2+ with IC50=13

ABT-100 - CAS# 450839-40-4 size:2mg solid MP-470 (10 μM) inhibits c-MetABT 100, CAS No. 450839 40 4, is an orally bioavailable farnesyltransferase inhibitor. ABT 100 inhibited proliferation of cells in vitro carrying oncogenic H Ras (EJ 1 bladder; IC(50) 2. 2 nmol L), Ki Ras (DLD 1 colon, MDA MB 231 breast, HCT 116 colon, and MiaPaCa 2 pancreatic; IC(50) range, 3. 8 9. 2 nmol L), and wild type Ras (PC 3 and DU 145; IC(50), 70 and 818 nmol L, respectively) as well as clonogenic potential. ABT 100 shows 70% to 80% oral