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Ponatinib hydrochloride
Smiles: CCOC(=O)C1=CC=C(C=C1)C1C=CC(=CC=1)OC(=O)N(C)CC1=CC=CC(=C1)C1=CC=NC=C1
Hum Mol Genet
T16A(inh) A01
H2O/c7-4(8)6(10
PF-670462 2HCl - CAS# 950912-80-8 Catalog No.:M6553-10 Ponatinib hydrochloridePF 670462 2HCl, CAS No. 950912 80 8, is a potent inhibitor of the CK1 isoforms CK1 and CK1 (IC50 = 7. 7 and 14 nM, respectively). Inhibition of CKIepsilon yields a perturbation of oscillator function that forestalls light as a zeitgeber, and they demonstrate that pharmacological tools such as PF 670462 may yield valuable insight into clock function. Casein kinase Iepsilon (CKIepsilon) is an essential component of the biological clock, phosphorylating