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4-dimethoxyphenyl)propanamide
InChiKey: WJNBSTLIALIIEW-UHFFFAOYSA-N
Chemical Name: N-(3-chloro-5-fluorophenyl)-4-nitrobenzo[c][1
resulting in inhibition of ligand-independent leukemic cell proliferation and apoptosis
Bywater MJ
EPZ-6438 - EZH2 Methyltransferase Inhibitor. CAS# 1403254-99-8 nsferase 4-dimethoxyphenyl)propanamideEPZ 6438 (E7438), CAS No. 1403254 99 8, is a potent and selective small molecule inhibitor of histone methyltransferase EZH2. It inhibited the activity of human PRC2 containing wild type EZH2 with an inhibition constant (Ki) value of 2. 5 0. 5 nM, and similar potency was observed for EZH2 proteins bearing all known lymphoma change of function mutations. EPZ 6438 inhibits EZH2 in a manner competitive with the substrate S adenosylmethionine (SAM). EPZ
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