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Smiles: COC1=CC2=CC(=CC(=O)C(O)=C2C(O)=C1O)C(=O)OCCCCCC
1]heptan-2-yl]-5-(2-nitrobenzoyl)-1
17)18)6(30-36(22
Chemical Name: 3-({4-hydroxy-1-[(3R
Chemical Name: 3-{[2-(4-fluorophenyl)ethyl]amino}-1-methyl-4-(2-methyl-1H-indol-3-yl)-2
TCS 2002 iclopirox Smiles: COC1=CC2=CC(=CC(=O)C(O)=C2C(O)=C1O)C(=O)OCCCCCCTCS 2002 is a potent inhibitor of GSK 3 with IC50 value of 35 nM . Glycogen synthase kinase 3 (GSK 3) is a serine threonine protein kinase and functions by phosphorylating a serine or threonine residue on its target protein. GSK3 plays an important role in neuronal cell development, energy metabolism and body pattern formation. TCS 2002 is a potent GSK 3 inhibitor with IC50 value of 35 nM. (S) TCS 2002 and (R) TCS 2002 inhibited GSK 3 with IC50 values
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