Vinorelbine ine hydrobromide LY364947 inhibits in vivo Smad2

LY364947 inhibits in vivo Smad2 phosphorylation within the NMuMg cells with IC50 of 135 nM

Smiles: CC1C=NC(=CC=1)C1C=CC(C)=CN=1

and dosing every four days causes 63% tumor growth inhibition (TGI)

Prestwick_908

5S)-2-[(2S)-2-amino-2-(3-hydroxyadamantan-1-yl)acetyl]-2-azabicyclo[3

Vinorelbine ine hydrobromide LY364947 inhibits in vivo Smad2Vinorelbine is a semisynthetic vinca alkaloid derived from the leaves of the periwinkle plant (Vinca rosea) with antineoplastic activity. Vinorelbine binds to tubulin, thereby inhibiting tubulin polymerization into microtubules and spindle formation and resulting in apoptosis of susceptible cancer cells. Inhibition of mitotic microtubules correlates with antitumor activity, whereas inhibition of axonal microtubules seems to correlate with