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JNK and Erk1/2
6-trichloro-3-methoxy-5-methylphenoxy)-6-({[(2R
Formula: C27H35F3N4O11
The amount of mTOR
CAS Number: 71301-82-1
SR 1824 Catalog No.:M22508-C JNK and Erk1/2Ki = 10 nM SR 1824 is a non agonist PPAR ligand. Peroxisome proliferator activated receptor (PPAR) can be activated by the anti diabetes drugs known as thiazolidinediones, including rosiglitazone and pioglitazone. Phosphorylation of PPAR by cyclin dependent kinase 5 (Cdk5) leads to dysregulation of genes whose expression is altered in obesity, such as adiponectin. In vitro: In a previous study, SR1824 was characterized for its ability to block Cdk5