PFI-3 - SMARCA Bromodomains Inhibitor. CAS# 1819363-80-8 Catalog No.:M60175-10S Smiles: O=C(COC1C(Cl)=CC(Cl)=CC=1Cl)N/N=C/C1=CC=CN1

Smiles: O=C(COC1C(Cl)=CC(Cl)=CC=1Cl)N/N=C/C1=CC=CN1

Atglistatin was used at 10 μM final concentration in vitro and in cellular assays

Smiles: CN1CCN(CC1)C1CCN(CC1)C1=CC(OC)=C(C=C1)NC1=NC(NC2=CC=CC=C2S(=O)(=O)C(C)C)=C(Cl)C=N1

and inhibits the growth of two xenografted tumors in mice in vivo

Junutula JR

PFI-3 - SMARCA Bromodomains Inhibitor. CAS# 1819363-80-8 Catalog No.:M60175-10S Smiles: O=C(COC1C(Cl)=CC(Cl)=CC=1Cl)N/N=C/C1=CC=CN1PFI 3, CAS No. 1819363 80 8, is a novel potent, selective and cell permeable inhibitor of SMARCA4 and PB1(5) bromodomains with IC50 ~ 89 nM and 48 nM respectively. It also inhibits SMARCA2, but has no interaction with the other sub family branches including PB1(2 4) and a kinase panel of 36 kinases. It accelerates FRAP recovery in cells at a concentration of 1 M. The SWI SNF related, Matrix associated, Actin dependent Regulator of Chromatin (SMARC)