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but not H3K56ac as revealed by western blot analysis
Incubation of exponentially growing RaH3 and RaH5 with 1 μM canertinib accumulated the cells in the G1-phase of the cell cycle within 24 h of treatment without induction of apoptosis
(2010) Cell Stem Cell 7
N[C@@H](CC1C=CC(=CC=1)[N+]([O-])(CCCl)CCCl)C(O)=O
CAS Number: 1621175-65-2
JIB-04 (NSC693627) - Jumonji Histone Demethylase Inhibitor. CAS# 199596-05-9 0156 but not H3K56ac as revealedJIB 04 (NSC693627, E isomer), CAS No. 199596 05 9, is a potent, selective and cell permeable Jumonji histone demethylase inhibitor. Unlike the other known inhibitors, JIB 04 is not a competitive inhibitor of a ketoglutarate. It inhibits the demethylase activity of Jumonji enzymes in vitro, with IC50 ~230 nM for JARID1A (KDM5A), ~440 nM for JMJD2A (KDM4A) and JMJD2B (KDM4B), ~340 nM for JMJD2E (KDM2E), and ~1 M for JMJD3 (KDM6B) and JMJD2C (KDM4C). JIB
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