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It inhibits IDH1 R132H mutant and R132C mutant in vitro with IC50 ~0
The binding mode of PNU-74654 involves the two narrow pockets on either side of this hot spot[2]
InChiKey: JOOXCMJARBKPKM-UHFFFAOYSA-N
15-hydroxy PGDH could catalyze the oxidation of primary PGs to their 15-keto metabolites
SU3327 also inhibits protein-protein interactions between JNK and JNK Interacting Protein (JIP) with an IC50 of 239 nM
Hydroxytyrosol acetate g-Phe amide It inhibits IDH1 R132H mutantHydroxytyrosol acetate is found in the olive oil with an antioxidant activity. Hydroxytyrosol acetate had a weaker DPPH radical scavenging activity than hydroxytyrosol. Product information CAS Number: 69039 02 7 Molecular Weight: 196. 20 Formula: C10H12O4 Chemical Name: 2 (3,4 dihydroxyphenyl)ethyl acetate Smiles: CC(=O)OCCC1=CC(O)=C(O)C=C1 InChiKey: FGJGLFPNIZXRLV UHFFFAOYSA N InChi: InChI=1S C10H12O4 c1 7(11)14 5 4 8 2 3 9(12)10(13)6 8 h2 3,6,12
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