GSK484 hydrochloride ty H Smiles: COC1C=CC(=CC=1)C1N=C(C2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)N(CC2C=CC(=CC=2)C(N)=O)C=1C1C=CC(=CC=1)OC

Smiles: COC1C=CC(=CC=1)C1N=C(C2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)N(CC2C=CC(=CC=2)C(N)=O)C=1C1C=CC(=CC=1)OC

InChiKey: PIAFFJUUNXEDEW-PXPMWPIZSA-N

InChiKey: RYMZZMVNJRMUDD-HGQWONQESA-N

27-/m1/s1/i3D

14-Dihydrosanguinarine

GSK484 hydrochloride ty H Smiles: COC1C=CC(=CC=1)C1N=C(C2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)N(CC2C=CC(=CC=2)C(N)=O)C=1C1C=CC(=CC=1)OCGSK484 hydrochloride is a selective and reversible peptidylarginine deiminase 4 (PAD4) inhibitor. GSK484 hydrochloride demonstrates high affinity binding to PAD4 with IC50s of 50 nM in the absence of Calcium. In the presence of 2 mM Calcium, notably lower potency (250 nM) is observed. Product information CAS Number: 1652591 81 5 Molecular Weight: 510. 03 Formula: C27H32ClN5O3 Chemical Name: (3S,4R) 3 amino 1 {2 [1 (cyclopropylmethyl) 1H indol 2 yl] 7