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Retaspimycin
343(2):239-48
and has the potential in targeting eIF4E for solid cancers
1221 and 4807 nM for Ramos cathepsin S
Electrophysiological Studies
BIBS 39 odoHoechst 33258 RetaspimycinBIBS 39 is a new nonpeptide angiotensin II (AII) receptor antagonist. Target: Angiotensin Receptorin vitro: BIBS 39 displaces [125I] AII from its specific binding sites with a Ki value of 29 7 nM for the AII subtype 1 (AT1) receptor and a Ki value of 480 110 nM for the AII subtype 2 (AT2) receptor. BIBS 222 shows a Ki value of 20 7 nM for the AT1 subtype and a Ki value of 730 170 nM for the AT2 subtype. BIBS 39 is 17 times more selective for the AT1
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