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Neumaier B
BI-7273 was used at 1-10 µM in vitro and cellular assays
Smiles: CN(CC1=CC2=NC(=NC(=C2S1)N1CCOCC1)C1=CN=C(C=C1)OC)C1N=CC(=CN=1)C(=O)NO
PubMed PMID: 26738988
8-tetrahydro-4H-pyrano[4
CPI-0610 - CAS# 1380087-89-7 0215 Neumaier BCPI 0610, also known as Pelabresib, CAS No. 1380087 89 7, is a small molecule inhibitor of the Bromodomain and Extra Terminal (BET) family of proteins, with potential antineoplastic activity. Upon administration, the BET inhibitor CPI 0610 binds to the acetylated lysine recognition motifs on the bromodomain of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histone peptides. This disrupts chromatin remodeling
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