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The pharmacokinetic (PK) profiles of PDK4-IN-1 (compound 8c) are evaluated in rat
Rat hepatocarcinoma cells (FAO) stimulated by fetal calf serum (FCS) exhibits a significant proportion in S phase (32
In August 2012
2-3H3/t24-
PubMed PMID: 27306340
(R)-CR8 trihydrochloride Size:10mg solid The pharmacokinetic (PK) profiles of(R) CR8 (CR8) trihydrochloride, a second generation analog of Roscovitine, is a potent CDK1 2 5 7 9 inhibitor. (R) CR8 trihydrochloride inhibits CDK1 cyclin B (IC50=0. 09 M), CDK2 cyclin A (0. 072 M), CDK2 cyclin E (0. 041 M), CDK5 p25 (0. 11 M), CDK7 cyclin H (1. 1 M), CDK9 cyclin T (0. 18 M) and CK1 (0. 4 M). (R) CR8 trihydrochloride induces apoptosis and has neuroprotective effect. (R) CR8 trihydrochloride acts as a molecular glue degrader that
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