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Colo205-R cells (IC50: >10 μM) are >300-fold more resistant to Ingenol Mebutate than parental Colo205-S cells
1'-biphenyl]-2-carboxamido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxamide
InChi: InChI=1S/C26H32N8O3/c1-6-20(35)33-11-7-8-18(13-33)34-25-22(24(27)28-14-29-25)23(31-34)26(37)30-19-10-9-17(15(2)16(19)3)12-21(36)32(4)5/h6
Chemical Name: 1H-Pyrrole-1-acetic acid
07 µM and ~0
CL-387785 - CAS# 194423-06-8 Catalog No.:M7079-10 Colo205-R cells (IC50: >10 μM)CL 387785, CAS No. 194423 06 8, also known as EKI 785 , is a n irreversible inhibitor of EGF receptor (EGFR) kinase activity in vivo (IC50 = 250 490 pM). CL 387785 covalently bound to EGF R. It also specifically inhibited kinase activity of the protein (IC50 = 370+ 120 pM), blocked EGF stimulated autophosphorylation of the receptor in cells (ic50 approximately 5 nM), inhibited cell proliferation (IC50 = 31 125 nM) primarily in a cytostatic manner in
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