CDK9-IN-1 - CAS# 1415559-43-1 pazide Maleate Smiles: COC1=C(C(F)=CC2=C1N(C=C(C(O)=O)C2=O)C1CC1)N1C[C@@H]2CCCN[C@@H]2C1

Smiles: COC1=C(C(F)=CC2=C1N(C=C(C(O)=O)C2=O)C1CC1)N1C[C@@H]2CCCN[C@@H]2C1

ACT 132577

CAS Number: 85650-52-8

which is a Class III antiarrhythmic and a multi-channel blocker for atrial fibrillation

1374639-75-4 (Butanedioic acid)

CDK9-IN-1 - CAS# 1415559-43-1 pazide Maleate Smiles: COC1=C(C(F)=CC2=C1N(C=C(C(O)=O)C2=O)C1CC1)N1C[C@@H]2CCCN[C@@H]2C1CDK9 inhibitor is a small molecule selective inhibitor of CDK9 (cyclin dependent kinase 9) with IC50 value of 39 nM. CDKs are a group of serine threonine kinases and are widely spread in all known eukaryotes. CDKs are activated through binding to cyclins and forming heterodimers. In the dimer, CDK acts as a catalytic subunit and phosphorylates the down stream proteins such as nuclear lamina protein, nucleolin and histone H1. Through this way, CDKs