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InChiKey: KVBQCJXMSFJOFP-UHFFFAOYSA-N
vitamin E phosphate
ClH/c1-12-10-15(30-18-22-24-25-27(18)9-8-26(2)3)28-16(20-12)21-17(23-28)29-11-13-4-6-14(19)7-5-13
5-bisphosphate (PIP2) depletion and slow agonist-induced desensitization of protease-activated receptor 2 (PAR2)
(2010) Leukemia
Tenovin-6 - CAS# 1011557-82-6 cetrapib InChiKey: KVBQCJXMSFJOFP-UHFFFAOYSA-NTenovin 6, also known as Tnv 6, is a bioactive small molecule SIRT2 inhibitor with anti neoplastic activity. Inhibition of the Sirtuin class of protein deacetylases with activation of p53 function is associated with the pro apoptotic effects of Tnv 6 in many tumors. Tnv 6 causes non genotoxic cytotoxicity, without adversely affecting human clonogenic hematopoietic progenitors in vitro, or murine hematopoiesis. Mechanistically, exposure of CLL cells to
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