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This specific panel is from Doctor Octopus's first appearance in Amazing Spider-Man #3, from 1963, written by Stan Lee and with art by Steve Ditko
That's what head designer Mark Rosewater seemed to suggest earlier this month anyway, as he recently claimed that Universes Beyond isn't "an endless well", and that there are a finite number of franchises to cross over with that will be popular
Note: Your creature doesn't have to survive the fight to get the artifact removal, you just have to deal excess damage
As you go through this list you'll see an impressive array of spells that you'd be happy to play, but most of the creatures that are still interesting are either recent additions or more than just a regular creature