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Belinostat (PXD101) Catalog No.:M22445-C PubMed PMID: 31773093

SKU: 19956264575

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Description

PubMed PMID: 31773093

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CDK6/cyclin D1

Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux

Belinostat (PXD101) Catalog No.:M22445-C PubMed PMID: 31773093Belinostat (also known as PXD101) is a novel and potent hydroxamate type inhibitor of histone deacetylase (HDAC) that inhibits the activity of HDAC in Hela cell extracts with 50% inhibition concentration IC50 value of 27 nM. Belinostat has been found to significantly increase the acetylation of histones H3 and H4 and exerts cytotoxicity in a wide range of tumor cell lines. In the treatment of urothelial carcinoma cell lines, belinostat dose

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