Dinaciclib - CAS# 779353-01-4 Catalog No.:M10712-10 C[C@@H](CC)[C@H](N)C(=O)NCCN1CCOCC1

C[C@@H](CC)[C@H](N)C(=O)NCCN1CCOCC1

InChiKey: VJYKVCURWJGLPG-IQZGDKDPSA-N

InChiKey: DUPAJELXESPTNF-RNEKHSKBSA-N

CGS 21680A is the hydrochloride salt

Smiles: CC(C)N(C1=CC=C(F)C=C1F)C(=O)N1C=NN(C2=CC=C(Cl)C=C2Cl)C1=O

Dinaciclib - CAS# 779353-01-4 Catalog No.:M10712-10 C[C@@H](CC)[C@H](N)C(=O)NCCN1CCOCC1Dinaciclib, also known as SCH727965, is a potent CDK inhibitor with potential antineoplastic activity. Dinaciclib selectively inhibits cyclin dependent kinases CDK1, CDK2, CDK5, and CDK9 activity in vitro with IC(50) values of 1, 1, 3, and 4 nmol L, respectively. Compared with flavopiridol, Dinaciclib exhibits superior activity with an improved therapeutic index. Dinaciclib induced regression of established solid tumors in a range of mouse models