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Schultz PG
and the IC50 value of the compound against CaM-KII is 10 μg/mL
dark and at 0-4oC for short term (days to weeks) or -20oC for long term (months to years)
2010 Sep 22
inhibited PI3K γ and -δ(IC50 values of 83 and 235 nM
Bedaquiline Catalog No.:M8161-2 Schultz PGBedaquiline, also known as TMC207 and R207910, is a diarylquinoline anti tuberculosis drug, which was discovered by a team led by Koen Andries at Janssen Pharmaceutica. Bedaquiline blocks the proton pump for ATP synthase of mycobacteria. ATP production is required for cellular energy production and its loss leads to cell death, even in dormant or nonreplicating mycobacteria. It is the first member of a new class of drugs called the diarylquinolines.
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