AP 1903 - CAS# 195514-63-7 size:2mg solid Formula: C38H35N5O6S2

Formula: C38H35N5O6S2

orally active inhibitor of p38 mitogen-activated protein kinase

also known as Pimitespib

Abramochkin DV

1186/1471-2407-14-664

AP 1903 - CAS# 195514-63-7 size:2mg solid Formula: C38H35N5O6S2AP 1903, CAS No. 195514 63 7, also known as Rimiducid, is a lipid permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild type FKBP12 with 1000 fold lower affinity. This agent is used to homodimerize the Fv containing drug binding domains of genetically engineered receptors such as the iCD40