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The active metabolite of nabumetone is felt to be the compound primarily responsible for therapeutic effect
22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6/h1-4H
with IC50 of 47 nM[1]
Formula: C20H27ClN2O3
with Kis of 36 nM and 41 nM for human and rat ROCK-2
Sumanirole maleate - CAS# 179386-44-8 Catalog No.:M11393-2 The active metabolite of nabumetoneSumanirole, also known as PNU 95666, is a highly selective D2 receptor full agonist, the first of its kind to be discovered. It was developed for the treatment of Parkinson's disease and restless leg syndrome. While it has never been approved for medical use, it is a highly valuable tool compound for basic research to identify neurobiological mechanisms that are based on a dopamine D2 linked (vs. D1, D3, D4, and D5 linked) mechanism of action. Product