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PubMed Central PMCID: PMC3776636
S-adenosylmethionine
plays a key role in tumor cell proliferation and tumor vascularization
Tsisanova E
https://en
GGTI-298 TFA - CAS# 1217457-86-7 60002 PubMed Central PMCID: PMC3776636GGTI 298 TFA, CAS No. 1217457 86 7, is a potent geranylgeranyltransferase I (GGTase I) inhibitor with potential antitumor actrivity. GGTI 298 disrupts MAP kinase activation and G(1) S transition in Ki Ras overexpressing transformed adrenocortical cells. GGTI 298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin dependent kinase inhibitors. A potential mechanism for GGTI 298 antitumor activity. GGTI 298 arrests human tumor
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