PHA-680632 182 Smiles: CC(C)(C)S(=O)(=O)N[C@@H]1CC[C@H](CC1)C(=O)NC1=CC=C(C=N1)C(F)(F)F

Smiles: CC(C)(C)S(=O)(=O)N[C@@H]1CC[C@H](CC1)C(=O)NC1=CC=C(C=N1)C(F)(F)F

SU14813: a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity

AMI-1 was used at 10-30 µM final concentration in vitro and in cellular assays

Solubility: DMSO : ≥ 100 mg/mL (473

PLX-4720 treatment at 30 mg/kg/day significant inhibits the tumor growth of 8505c xenografts by >90%

PHA-680632 182 Smiles: CC(C)(C)S(=O)(=O)N[C@@H]1CC[C@H](CC1)C(=O)NC1=CC=C(C=N1)C(F)(F)FPHA 680632 is a is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. PHA 680632 is also the first representative of a new class of Aurora inhibitors with a high potential for further development as an anticancer therapeutic. PHA 680632 is active on a wide range of cancer cell lines and shows significant tumor growth inhibition in different animal tumor models at well tolerated doses. Product