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S-(+)-Arundic Acid ((S)ONO-2506) is the S-enantiomer of Arundic Acid
9-tetramethyldocosahydrospiro[naphtho[2'
SB-743921 (0
TAE684 induces apoptosis and G1 phase arrest in NPM-ALK-expressing Ba/F3 cells and ALCL patient cell lines
9 μM are obtained after 1 day of treatment with Reserpine hydrochloride in JB6 P+ and HepG2-C8 cells
AG-636 217903 S-(+)-Arundic Acid ((S)ONO-2506) is theAG 636 is a potent, reversible, selective and orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 17 nM. Differential AG 636 activity translated to the in vivo setting, with complete tumor regression observed in a lymphoma model. Dissection of the relationship between uridine availability and response to AG 636 revealed a divergent ability of lymphoma and solid tumor cell lines to survive and grow in the setting of depleted
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