![NNGH - CAS# 161314-17-6 798CG-100602 [O-]C(=O)C1=CC=CC=C1C1C2=CC(Br)=C([O-])C(Br)=C2OC2C=1C=C(Br)C(=O)C=2Br](https://cdn.shopify.com/s/files/1/0389/1897/9723/products/M22383_1635323051.gif?v=1742749446)
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[O-]C(=O)C1=CC=CC=C1C1C2=CC(Br)=C([O-])C(Br)=C2OC2C=1C=C(Br)C(=O)C=2Br
once-daily oral administration of vadadustat
14b-hexahydrodibenzo[c
InChiKey: YDIKCZBMBPOGFT-PWUSVEHZSA-N
Chemical Name: 1-cyclohexyl-3-[4-(1-hydroxyethyl)benzenesulfonyl]urea
NNGH - CAS# 161314-17-6 798CG-100602 [O-]C(=O)C1=CC=CC=C1C1C2=CC(Br)=C([O-])C(Br)=C2OC2C=1C=C(Br)C(=O)C=2BrKi: 9, 2. 6, 4. 3, 3. 1, and 17 nM for MMP 8, 9, 12, 13, and 20, respectively. NNGH is an inhibitor of MMPs. Matrix metalloproteinases (MMPs), a large class of strictly related zincdependent enzymes, belong to the family of proteolytic enzymes. MMPs are involved in various aspects of physiological cellular processes and pathologies, such as pulmonary emphysema, reumathoid arthritis, tumor growth and metastasis. In vitro: Previous study found that NNGH