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daily) exacerbates the cognitive impairments in all the measurements
which were suppressed by the treatment of tofogliflozin or an antioxidant N-acetylcysteine (NAC)
11-dioxa-14-azaheptacyclo[10
InChi: InChI=1S/C23H27NO4/c1-27-22-15-18(7-9-21(22)25)8-10-23(26)28-17-20-11-13-24(14-12-20)16-19-5-3-2-4-6-19/h2-10
pii: S0006-291X(20)30530-1
NDI-091143 Catalog No.:M32341-C daily) exacerbates the cognitive impairmentsNDI 091143 is a potent and high affinity human ATP citrate lyase (ACLY) inhibitor with an IC50 of 2. 1 nM (ADP Glo assay), a Ki of 7. 0 nM and a Kd of 2. 2 nM. NDI 091143 inhibits ACLY catalysis allosterically, by stabilizing large conformational changes in the citrate domain that indirectly block the binding and recognition of citrate. Product information CAS Number: 2375840 87 0 Molecular Weight: 453. 84 Formula: C20H14ClF2NO5S Chemical Name: methyl