MIRA-1 idinium bromide Fusidic acid sodium salt has

Fusidic acid sodium salt has no corticosteroid effects

Smiles: OC1C=CC(=CC=1)C1OC2=CC(=CC(O)=C2C(=O)C=1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

2)10-17(24)19(14)20/h9

93 L/kg in rats

Formula: C20H18ClN3O6

MIRA-1 idinium bromide Fusidic acid sodium salt hasMIRA 1 is a maleimide derived small molecule that reactivates the tumor suppressor function of mutant p53, inducing apoptosis in several human solid tumor cell lines carrying tetracycline regulated mutant p53 (IC50 = 10 M in vitro). 1 Treatment of tumor cells with MIRA 1 induces p21, MDM2 and PUMA in a mutant p53 dependent manner. At a concentration of 5 10 mg kg, MIRA 1, alone or in combination with dexamethasone , arrested tumor growth in a mouse