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CAS Number: 34540-22-2
InChi: InChI=1S/C22H17F2N5OS/c1-14(21-28-20(10-31-21)16-4-2-15(9-25)3-5-16)22(30
demonstrated approximately 10-fold higher affinity for human D3 versus human D2L and human D2S receptors (pKi 10
crosses the blood-brain barrier
Other intracellular receptors (AR
Semapimod tetrahydrochloride (disodium salt) CAS Number: 34540-22-2Semapimod tetrahydrochloride (CNI 1493), an inhibitor of proinflammatory cytokine production, can inhibit TNF , IL 1, and IL 6. Semapimod tetrahydrochloride inhibits TLR4 signaling (IC500. 3 M). Semapimod tetrahydrochloride inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod tetrahydrochloride has potential in a variety of inflammatory and autoimmune disorders. Product information CAS Number: 164301 51 3 Molecular Weight: 890. 74