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It is also a selective G protein-coupled receptor kinase 5 (GRK5) inhibitor
Formula: C15H20O2
InChi: InChI=1S/C10H12N4O3/c15-3-6-1-2-7(17-6)14-5-13-8-9(14)11-4-12-10(8)16/h4-7
CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)C3C=CC(O)=CC=3)C(=O)N2[C@H]1C([O-])=O
a c-Src/Abl kinase inhibitor
BML-277 nlafaxine It is also a selectiveBML 277, also known as Chk2 Inhibitor II, is a Chk2 (checkpoint kinase 2) inhibitor. BML 277 protects T cells from apoptosis by controlling the response of p53 to radiation induced DNA breaks. ML 277 has IC50 = 15 nM; Ki = 37 nM. ML 277 shows 1000 fold greater selectivity for the Chk2 serine threonine kinase than for the Cdk1 B and CK1 kinases (for which IC50 = 12 M and 17 M, respectively). Product information CAS Number: 516480 79 8 Molecular Weight:
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