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InChi: InChI=1S/C21H22O5/c1-13(2)10-15(22)11-14(3)6-8-25-21-16-4-5-20(23)26-19(16)12-18-17(21)7-9-24-18/h4-7
Santamarina E
InChiKey: IFYYFLINQYPWGJ-UHFFFAOYSA-N
3-trimethyl-2-oxabicyclo[2
2-a]pyrimidin-6-yl)cyclopropane-1-carbonitrile
OG-L002 HCl 2623 InChi: InChI=1S/C21H22O5/c1-13(2)10-15(22)11-14(3)6-8-25-21-16-4-5-20(23)26-19(16)12-18-17(21)7-9-24-18/h4-7OG L002 is a specific and potent inhibitor of lysine (K) specific demethylase 1A (LSD1) with IC50 value of 20 nM . LSD1 is a flavin dependent monoamine oxidase, which can demethylate lysines. LSD1 plays critical roles in oocyte growth, embryogenesis and tissue specific differentiation . OG L002 potently inhibited HSV IE gene expression in both HFF and HeLa cells with IC50 of ~3 M and ~10 M, respectively. OG L002 treatment can potently reduce