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KW-2449 can dephosphorylate constitutively active WT-FLT3 kinase but not inhibit the proliferation of leukemia cells if they are not mainly addicted to FLT3 the kinase
Chrysophanic acid also inhibits the replication of poliovirus types 2 and 3 (Picornaviridae) and poliovirus-induced cytopathic effects in BGM (Buffalo green monkey) kidney cells
InChiKey: SOLUWJRYJLAZCX-LYOVBCGYSA-N
In relevant biological assays
InChiKey: WOMPQPMHRDDZMP-IJBWYZRXSA-N
Anagliptin 1053 KW-2449 can dephosphorylate constitutively activeAnagliptin is a highly selective, potent inhibitor of dipeptidyl peptidase 4 (DPP 4), with an IC50 of 3. 8 nM, and less selective at DPP 8 9 (IC50, 68, 60 nM, respectively). Product information CAS Number: 739366 20 2 Molecular Weight: 383. 45 Formula: C19H25N7O2 Chemical Name: N [2 ({2 [(2S) 2 cyanopyrrolidin 1 yl] 2 oxoethyl}amino) 2 methylpropyl] 2 methylpyrazolo[1,5 a]pyrimidine 6 carboxamide Smiles:
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