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ROCK inhibition with the use of GSK 269962 in the 10 mg/kg dose
because its metabolites offer an alternative pathway to the urea cycle to allow excretion of excess nitrogen
Formula: C6H12ClNO
InChi: InChI=1S/C15H10FNO3/c1-2-8-5-10(18)7-12-14(8)20-15(17-12)9-3-4-13(19)11(16)6-9/h2-7
2H2O/c1-3-20-10-12(17(23)24)16(22)11-8-13(18)15(9-14(11)20)21-6-4-19(2)5-7-21
Bendamustine Hydrochloride ntan Hydrochloride ROCK inhibition with the useBendamustine is a bifunctional mechlorethamine derivative with alkylator and antimetabolite activities. Bendamustine possesses three active moieties: an alkylating group; a benzimidazole ring, which may act as a purine analogue; and a butyric acid side chain. Although its exact mechanism of action is unknown, this agent appears to act primarily as an alkylator. Bendamustine metabolites alkylate and crosslink macromolecules, resulting in DNA, RNA and
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