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Pomalidomide HCl Down-regulation of RhoA is involved

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Description

Down-regulation of RhoA is involved in the cytotoxic action of lipophilic statins in HepG2 cells

30(3):269-271

12:CD004694

MIC(90)s 0

the in vitro proliferation of MH3924A cells is increased (P<0

Pomalidomide HCl Down-regulation of RhoA is involvedPomalidomide, also known as CC4047, is an orally bioavailable derivative of thalidomide with potential immunomodulating, antiangiogenic and antineoplastic activities. Although its exact mechanism of action has yet to be fully elucidated, pomalidomide appears to inhibit TNF alpha production, enhance the activity of T cells and natural killer (NK) cells and enhance antibody dependent cellular cytotoxicity (ADCC). Pomalidomide was approved on February 8,

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