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J Pak Med Assoc
PCI-34051 has a unique mechanism of action involving PLCgamma1 activation and calcium-induced apoptosis
2006 Nov 15
also known as BMS-512148
Retinoid differentiation therapy for common types of acute myeloid leukemia
CAL-101 - CAS# 870281-82-6 richlormethiazide J Pak Med AssocIdelalisib, also known as CAL 101, is a PI3K delta inhibitor with potential immunomodulating and antineoplastic activities. CAL 101 inhibits the production of the second messenger phosphatidylinositol 3,4,5 trisphosphate (PIP3), preventing the activation of the PI3K signaling pathway and thus inhibiting tumor cell proliferation, motility, and survival. Unlike other isoforms of PI3K, PI3K delta is expressed primarily in hematopoietic lineages. The