Midostaurin-D5 569Tocopherol Smiles: CC(F)(F)[C@@H]1C[C@H]2CN(C1)CC1=C(NC3=CC=CC=C13)[C@](C2)(C1=CC2=C(C=C1OC)N(C)[C@@H]1[C@@]32CCN2CC=C[C@@](CC)([C@@H](OC(C)=O)[C@]1(O)C(=O)OC)[C@@H]32)C(=O)OC

Smiles: CC(F)(F)[C@@H]1C[C@H]2CN(C1)CC1=C(NC3=CC=CC=C13)[C@](C2)(C1=CC2=C(C=C1OC)N(C)[C@@H]1[C@@]32CCN2CC=C[C@@](CC)([C@@H](OC(C)=O)[C@]1(O)C(=O)OC)[C@@H]32)C(=O)OC

Pillarsetty NV

administration with no reduction of body weight in animals

Peptide and small molecule inhibitors of HECT-type ubiquitin ligases

Smiles: CN1C(=O)C(C)N(CCC(C)C)C2=NC(NC3=CC(F)=C(O)C(F)=C3)=NC=C12

Midostaurin-D5 569Tocopherol Smiles: CC(F)(F)[C@@H]1C[C@H]2CN(C1)CC1=C(NC3=CC=CC=C13)[C@](C2)(C1=CC2=C(C=C1OC)N(C)[C@@H]1[C@@]32CCN2CC=C[C@@](CC)([C@@H](OC(C)=O)[C@]1(O)C(=O)OC)[C@@H]32)C(=O)OCMidostaurin D5 (PKC412 D5) is a deuterium labeled Midostaurin. Midostaurin is a multi targeted protein kinase inhibitor which inhibits PKC , Syk, Flk 1, Akt, PKA, c Kit, c Fgr, c Src, FLT3, PDFR and VEGFR1 2 with IC50s ranging from 22 500 nM. Product information Molecular Weight: 575. 67 Formula: C35H30N4O4 Chemical Name: N [(2S,3R,4R,6R) 6 hydrogenio 3 methoxy 2 methyl 16 oxo 29 oxa 1,7,17 triazaoctacyclo[12. 12. 2. 1,. 0,. 0,. 0,. 0,. 0,]nonacosa