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6(3):372-83
VR23: A Quinoline-Sulfonyl Hybrid Proteasome Inhibitor That Selectively Kills Cancer via Cyclin E-Mediated Centrosome Amplification
and orally efficacious positive allosteric modulator of α7 nicotinic acetylcholine receptor (α7 nAChR)
Formula: C19H12O7
1781828-85-0
PKC-IN-1 - CAS# 1046787-18-1 size:10mg solid 6(3):372-83PKC IN 1, CAS No. 1046787 18 1, is a potent, ATP competitive and reversible inhibitor of conventional PKC enzymes with Kis of 5. 3 and 10. 4 nM for human PKC and PKC, and IC50s of 2. 3, 8. 1, 7. 6, 25. 6, 57. 5, 314, 808 nM for PKC, PKCI, PKCII, PKC, PKC, PKC mu and PKC, respectively. IC50: 2. 3 nM (Human PKC), 7. 6 nM (Human PKCII), 8. 1 nM (Human PKCI), 25. 6 nM (Human PKC), 57. 5 nM (Human PKC), 314 nM (Human PKC mu), 808 nM (Human PKC) Ki: 5. 3 nM
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