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Colony formation assay reveals that treatment with 10 μM Caffeic acid phenethyl ester reduces colony formation of LNCaP 104-R1 cells by 90% while treatment with 20 μM Caffeic acid phenethyl ester completely blocks the formation of LNCaP 104-R1 colonies
Brain penetrant
CID5721353 (Compound 79-6) specifically inhibits BCL6 repressor activity
4-tetrazol-5-yl)-[1
InChi: InChI=1S/C20H23NO4/c1-21(2)8-7-12-10-15(25-4)20(23)18-16(12)13(21)9-11-5-6-14(24-3)19(22)17(11)18/h5-6
10-DEBC hydrochloride 15453 Colony formation assay reveals thatAkt functions as a key component in multiple signaling pathways to promote cell survival by mediating resistance to apoptosis. Akt inhibitor X is a cell permeable phenoxazine derivative that suppresses insulin like growth factor 1 (IGF 1) stimulated phosphorylation of Akt with an IC50 value of 1 2 M. This compound has been shown to block IGF 1 stimulated nuclear translocation of Akt in Rh1 cells and to inhibit the growth of Rh1, Rh18, and Rh30 cells