Ro 48-8071 fumarate - CAS# 189197-69-1 Size:Solid 10 mg YH239-EE induces cell cycle arrest

YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53

and alterations in prostaglandin synthesis and degradation

5]nonan-2-yl)pyrimidin-5-yl)oxy)benzamide

3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoate

Quetiapine S-oxide

Ro 48-8071 fumarate - CAS# 189197-69-1 Size:Solid 10 mg YH239-EE induces cell cycle arrestRo 48 8071 is an orally active cholesterol synthesis inhibitor or a 2,3 oxidosqualene: lanosterol cyclase (OSC) inhibitor. OSC (EC 5. 4. 99. 7) represents a unique target for a cholesterol lowering drug. Partial inhibition of OSC should reduce synthesis of lanosterol and subsequent sterols, and also stimulate the production of epoxysterols that repress HMG CoA reductase expression, generating a synergistic, self limited negative regulatory loop.