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YM-155 - a survivin inhibitor. CAS# 781661-94-7 0263 Castilla LH

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Description

Castilla LH

Smiles: CN1CCN(CC1)C1=CC=C(C=C1NC(=O)C1=CNC(=O)C=C1C(F)(F)F)C1=CC(CN2CCOCC2)=CC=C1

WHI-P154 (4 μM) moderately sensitizes ABCB1-overexpressing KB-C2 cells to its substrates whereas shows no sensitizing effect on ABCC1-

(2011) Proc Natl Acad Sci USA

and growth is inhibited for all cell lines tested

YM-155 - a survivin inhibitor. CAS# 781661-94-7 0263 Castilla LHYM 155, CAS No. 781661 94 7, is a novel survivin suppressant with an IC50 of 0. 54 nM for the inhibition of survivin promoter activity. Sepantronium bromide, also known as YM 155, is a small molecule proapoptotic agent with potential antineoplastic activity. Survivin inhibitor YM155 selectively inhibits survivin expression in tumor cells, resulting in inhibition of survivin antiapoptotic activity (via the extrinsic or intrinsic apoptotic pathways) and

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