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DCC-2036 t N-oxide It displayed greater than 23-fold

SKU: 36385913829

4.6
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Description

It displayed greater than 23-fold selective inhibition of the breast CSC-like cell line (HMLE_sh_Ecad) over the isogenic control cell line (HMLE_sh_GFP)

CAS Number: 844499-71-4

InChi: InChI=1S/C10H12N4O5

Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid

and c-Met-T1010I with IC50 of 3

DCC-2036 t N-oxide It displayed greater than 23-foldDCC 2036, is an orally bioavailable small molecule inhibitor of multiple tyrosine kinases with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor DCC 2036 binds to and inhibits the Bcr Abl fusion oncoprotein by changing the conformation of the folded protein to disallow ligand dependent and ligand independent activation; in addition, this agent binds to and inhibits Src family kinases LYN, HCK and FGR and the receptor tyrosine

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